Discovery Talk: Discovery of Chaperonin-Assisted Protein Folding

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Recorded: 2012
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Research Paper Discussed in this Talk

Cheng MY, Hartl FU, Martin J, Pollock RA, Kalousek F, Neupert W, Hallberg EM, Hallberg RL, Horwich AL. Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature. 1989 Feb16;337(6208):620-5.

Educator Resources (Educators only)

These questions and answers were designed to link the iBiology video to the research paper and for use as a classroom activity.

Prepared by Dr. Nathan H. Joh.

Questions and answers for this talk and related paper >>

About this Talk

Dr. Horwich explains that his lab was studying the import and folding of mitochondrial proteins in yeast mutants when he, and his collaborator Ulrich Hartl, discovered Hsp 60, a mitochondrial matrix protein required for proper folding of imported proteins. Hsp60 was found to have homology with proteins from bacteria and plants leading to the discovery of the molecular chaperonin protein family and its role in protein folding.

This video is located in: iBioMagazine Issue 10

About the Speaker

Arthur Horwich is the Sterling Professor of Genetics and Professor of Pediatrics at Yale School of Medicine and a Howard Hughes Medical Institute Investigator.  Using genetics, biochemistry and biophysics, his lab studies the mechanism of action of chaperonins and, more recently, the neurodegenerative diseases resulting from protein misfolding.  Horwich has received the Lasker Award and The Shaw Prize, amongst other awards, and he is a member of the National Academy of Sciences.

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  1. Doug Easton says

    I am showing this to my graduate course Protein Folding and Disease. I had the lucky opportunity to talk with Al at a CSHL Heat Shock meeting. We shared a room and I had the opportunity to have him ask questions about our uncovering of hsp110 as a large Hsp70 family member in John Subjeck’s lab. His pointed questions made my thinking clearer. I think that this wonderful presentation will make Chaperoning clearer to my students.

    Keep making these great videos!!

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