Discovery Talk: Developing GFP as a Biological Marker

Download: This Video Subtitled Videos: English
Resources: Transcript (.txt)(.xls)
Trouble Viewing? Try it on iTunes.Report a problem.

Research Paper Discussed in this Talk

Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC. (1994) Green fluorescent protein as a marker for gene expression. Science. Feb 11;263(5148):802-5.

Educator Resources (Educators only)

These questions and answers were designed to link the iBiology video to the research paper and for use as a classroom activity.

Questions and answers for this talk and related paper >>

About this Talk

Chalfie describes the events, both serendipitous and insightful, that led to the discovery that the green fluorescent protein (GFP) could be used to track the expression and localization of proteins, thus revolutionizing modern cell biology. He also presents a strong argument for the importance of basic research in moving science forward.

This video is located in: iBioMagazine Issue 4

About the Speaker

Martin Chalfie is a Professor of Biological Sciences at Columbia University, where his lab investigates the development and function of touch sensitive nerve cells in C. elegans. In 1988, Chalfie realized that GFP had great potential as a marker of gene expression in living cells and, with his colleagues, he went on to develop this revolutionary technique. He shared the Nobel Prize in Chemistry in 2008 for this work.

Related Talks

Speak Your Mind