Discovery Talk: Developing GFP as a Biological Marker

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Research Paper Discussed in this Talk

Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC. (1994) Green fluorescent protein as a marker for gene expression. Science. Feb 11;263(5148):802-5.

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About this Talk

Chalfie describes the events, both serendipitous and insightful, that led to the discovery that the green fluorescent protein (GFP) could be used to track the expression and localization of proteins, thus revolutionizing modern cell biology. He also presents a strong argument for the importance of basic research in moving science forward.

This video is located in: iBioMagazine Issue 4

About the Speaker

Martin Chalfie is a Professor of Biological Sciences at Columbia University, where his lab investigates the development and function of touch sensitive nerve cells in C. elegans. In 1988, Chalfie realized that GFP had great potential as a marker of gene expression in living cells and, with his colleagues, he went on to develop this revolutionary technique. He shared the Nobel Prize in Chemistry in 2008 for this work.

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