Discovery Talk: Unfolding the UPR

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Research Paper Discussed in this Talk

Cox JS, Walter P. (1996). A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell, Nov 1;87(3):391-404.

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These questions and answers were designed to link the iBiology video to the research paper and for use as a classroom activity.

Prepared by Dr. Yi Liu.

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About this Talk

Proteins that are secreted from the cell or inserted into the plasma membrane transit through the endoplasmic reticulum, where they are properly folded and assembled and may undergo post-translational modification. Walter tells the story of the exciting discovery made in his lab of the “unfolded protein response”, a feedback pathway that ensures that the cell makes enough ER to properly modify all the secreted proteins in the cell.

This video is located in: iBioMagazine Issue 1

About the Speaker

Peter Walter is a Professor of Biochemistry and Biophysics at the University of California, San Francisco, and a Howard Hughes Medical Institute Investigator. His lab studies how cells regulate the quantity of their organelles and how proteins localize to the right place within a cell. Walter is also a long-time co-author of “The Molecular Biology of the Cell”, one of the most widely used textbooks in the field. In 2014, Walter was awarded the Shaw Prize and the Albert Lasker Basic Medical Research Award for his research. 

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