Week 9: Cell Cycle

By David Morgan (University of California, San Francisco)

Discussion Question

Discuss strategies used to identify CDK substrates, and why some of these substrates (e.g. DNA replication proteins) bind CDK better during S-phase than during M-phase.

Protein Phosphorylation in Biology

Length: 28:31 minDownload: This Video
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Architecture of a Protein Kinase

Length: 30:08 minDownload: This Video
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Course Materials

Assignment and Quiz Questions and Answers (Educators Only)

Lecture Overview

Part 1: Cells reproduce by duplicating their chromosomes and other components and then distributing them into a pair of genetically identical daughter cells. This series of events is called the cell cycle. In the first part of this lecture, I provide a general overview of the cell-cycle control system, a complex regulatory network that guides the cell through the steps of cell division. I briefly describe the major components of this regulatory system and how they fit together to form a series of biochemical switches that trigger cell-cycle events at the correct time and in the correct order.

Part 2: Cyclin-dependent kinases (Cdks) are the central components of the control system that initiates the events of the cell cycle. In the second part of this lecture, I discuss my laboratory’s efforts to address the problem of how the Cdks trigger cell-cycle events. I describe our methods for identifying the protein substrates of the Cdks, and I discuss how these studies have led to important clues about how Cdks find their correct targets in the cell and how phosphorylation of those targets governs their function.

Speaker Bio

David Morgan is a Professor in the Departments of Physiology and Biochemistry & Biophysics at the University of California, San Francisco (UCSF). He received an undergraduate degree in animal physiology from the University of Calgary in 1980, followed in 1986 by a PhD from UCSF, with Richard Roth.

Following postdoctoral studies with William Rutter and Harold Varmus at UCSF, he started his own laboratory there in 1990. His research interests are centered on the biochemical mechanisms and regulatory circuits that govern cell-cycle progression.


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