Mario Capecchi: The Birth of Gene Targeting

If you strongly believe in an idea, sometimes you need to take some risks to pursue it. This is part of Dr. Capecchi’s message as he describes the challenges in developing the technique of gene targeting from tissue culture cells to mice.

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Research Paper Discussed in this Talk

Capecchi MR. (2005). Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet, Jun;6(6):507-12. Review.

Educator Resources (Educators only)

These questions and answers were designed to link the iBiology video to the research paper and for use as a classroom activity.

Prepared by Dr.Yi Liu.

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About the Speaker

Dr. Capecchi is Distinguished Professor of Human Genetics and Biology at the University of Utah and a Howard Hughes Medical Institute Investigator. He is best known for his work on the development of gene targeting in mouse embryonic stem cells. Capecchi was awarded the 2007 Nobel Prize for Medicine or Physiology, with Oliver Smithies and Martin Evans, for his contributions to this field.

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