Part I: How Does Complexity Arise from Molecular Interactions?
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A eukaryotic cell is often 5-6 orders of magnitude larger than the molecules that make it up. How is it that these molecules interact to organize the complex structures that constitute a cell?
In part 1 of his seminar, Dr. Hyman explains how cell division in a C. elegans embryo provides an excellent model for organization of cellular structures and processes and how RNA interference (RNAi) is an extremely useful tool to study this model. He describes how individual proteins can form complexes of varying size and complexity. Complexes can then organize to form compartments, or non-membrane bound organelles such as centrosomes or the cell cortex, and the organization of these compartments drives the organization of cells. In parts 2, 3 and 4 of his talk, Hyman explains what is known about the organization of increasingly larger and more complex cell structures: the microtubules of the mitotic spindle, centrioles, and finally, P granules. He also discusses the necessity of bringing the tools of physics, chemistry and molecular biology to bear, in addressing the complexity of the cell.
Tony Hyman received his BSc in Zoology from University College, London. He did his first experiments on C. elegans as a PhD student in the Laboratory of Molecular Biology, King’s College, Cambridge. He then moved to the University of California, San Francisco to pursue postdoctoral research with Tim Mitchison. In 1993, Hyman moved to the EMBL in Heidelberg and in 1999 he became a Director of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden.
Hyman’s lab studies the spatial control of the microtubule cytoskeleton and how this affects mitosis and cell division. Much of his research uses the technique of RNA interference in C. elegans embryos but some experiments study human cells using bacterial artificial chromosomes (BAC) transgenesis.
- Tim Mitchison iBioSeminar: Self-Organization of Microtubule Assemblies
- Roy Parker iBioSeminar: P-Bodies and the mRNA Cycle
- Gary Borisy and Ed Taylor iBioMagazine: The Discovery of Tubulin
- Margaret Gardel iBioMagazine: What is Cytoplasm
- Michael Rosen: Physical Mechanisms of Cell Organization on Micron Length Scales
- Julie Theriot iBioMagazine: Discovering Design Principles for Cells and Organisms