Ira Mellman: Cell Biology of the Immune Response

I. Cellular Basis of the Immune Response
II. Antigen Presentation and Dendritic Cells

Part II: Antigen Presentation and Dendritic Cells

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Lecture Overview
The immune system is charged with protecting us from invading microorganisms, a task that falls to a complex array of highly specialized cell types spread throughout the body but that must work together as an integrated system. How they accomplish and perform their functions can be wonderfully understood by probing the basic mechanisms governing their activities. In the first video, we will consider the overall organization of the immune response in cellular terms, the innate immune system (comprising evolutionarily ancient phagocytic cells that recognize conserved molecules of microorganisms) and the adaptive immune system (composed of lymphocytes that recognize chemically diverse antigens). More >>

Speaker Bio
Ira Mellman is Vice President of Research Oncology at Genentech. Ira is a cell biologist with a long standing interest in membrane traffic. His lab is reponsible for key observations leading to the initial discovery of endosomes, the mechanisms of epithelial cell polarity, and the cellular basis of dendritic cell function.

Until 2007, Ira was Chair of the Department of Cell Biology at Yale University School of Medicine where he also served as Sterling Professor of Cell Biology and Immunobiology and part of the Ludwig Institute for Cancer Research. More >>

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