Part I: Polyketide Biosynthesis
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In the first part, an overview of polyketides and polyketide biosynthesis is presented. A rationale for investigating polyketide biosynthesis is also presented. In the second part, the contributions of genetics and molecular biology on investigations into erythromycin biosynthesis are summarized. The impact of these fields on biosynthetic engineering is also explained. In the final part, the enzymology of the erythromycin polyketide synthase is discussed.
Chaitan Khosla is Professor of Chemistry, Chemical Engineering, and, by courtesy, of Biochemistry at Stanford University. He received his PhD in 1990 at Caltech. After completing postdoctoral studies at the John Innes Centre in the UK, he joined Stanford in 1992.
Over the past two decades he has studied polyketide synthases as paradigms for modular catalysis, and has exploited their properties for engineering novel antibiotics.