Jim Haber: Mechanisms of DNA Repair

I. Mechanisms of DNA Repair by Recombination
II. Details of DNA Repair in Budding Yeast

Part II: Details of DNA Repair in Budding Yeast

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Lecture Overview
Part 1. The most deleterious form of DNA damage is a double-strand break (DSB), which can arise from errors in DNA replication, from the failure of topoisomerases to complete their cycles of DNA cutting and rejoining, from mechanical stress and from the action of endonucleases that cleave DNA. Here we review how DSBs can be repaired either by non-homologous end-joining mechanisms or by several homologous recombination pathways including single-strand annealing, gene conversion and break-induced replication. More >>

Speaker Bio
Jim Haber is Professor of Biology and Director of the Rosenstiel Basic Medical Sciences Research Center at Brandeis University, in the Boston MA suburbs. He received his A.B. degree in Biochemical Sciences at Harvard College and his Ph.D. in Biochemistry at U.C. Berkeley. After postdoctoral training at the University of Wisconsin in Madison he joined the faculty at Brandeis University. He is a Fellow of the American Association for the Advancement of Science, the American Academy of Microbiology and the American Academy of Arts and Sciences. More >>

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