I. Split Genes and RNA Splicing
II. Spliceosome Structure and Dynamics
Part I: Split Genes and RNA Splicing
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In the first part of her talk, Dr. Moore explains that eukaryotic pre-mRNA contains long stretches of non-protein coding sequences interspersed with protein coding regions. By recognizing specific sequences, cellular machinery splices out the non-coding introns leaving just the protein-coding exons in mRNA. Although at first glance this may seem like a wasteful process, it is splicing that facilitates the evolution of new genes, and alternative splicing that allows a limited number of genes to produce a large number of proteins. More >>
Melissa Moore received her PhD in biological chemistry from the Massachusetts Institute of Technology. She became interested in understanding RNA splicing during a post-doc with Phillip Sharp, also at MIT. Since then, Moore has spent much of her career working on the spliceosome and other mysteries of RNA processing. Currently, Moore is a Howard Hughes Medical Institute Investigator, a Professor of Biochemistry and Molecular Pharmacology, and co-director of the RNA Therapeutics Institute at the University of Massachusetts Medical School.
- Tom Cech iBioEducation Discovery Talk: Discovering Ribozymes
- Joan Steitz iBioMagazine: The Discovery of SNURPs
- Anna Marie Pyle iBioSeminar: RNA Structure, Function and Recognition
- Melissa Moore Short Clip: Exons and Introns
- Roy Parker iBioSeminar: mRNA Localization, Translation and Degradation
- Phillip A. Sharp's iBioMagazine: RNA Splicing: What is a Gene?
- Robert Tjian iBioSeminar: The Molecular Biology of Gene Regulation