I. Split Genes and RNA Splicing
II. Spliceosome Structure and Dynamics
Part II: Spliceosome Structure and Dynamics
|Download:||This Video Subtitled Videos: English|
|Trouble Viewing? Try it on iTunes.Report a problem.|
In the first part of her talk, Dr. Moore explains that eukaryotic pre-mRNA contains long stretches of non-protein coding sequences interspersed with protein coding regions. By recognizing specific sequences, cellular machinery splices out the non-coding introns leaving just the protein-coding exons in mRNA. Although at first glance this may seem like a wasteful process, it is splicing that facilitates the evolution of new genes, and alternative splicing that allows a limited number of genes to produce a large number of proteins. More >>
Melissa Moore received her PhD in biological chemistry from the Massachusetts Institute of Technology. She became interested in understanding RNA splicing during a post-doc with Phillip Sharp, also at MIT. Since then, Moore has spent much of her career working on the spliceosome and other mysteries of RNA processing. Currently, Moore is a Howard Hughes Medical Institute Investigator, a Professor of Biochemistry and Molecular Pharmacology, and co-director of the RNA Therapeutics Institute at the University of Massachusetts Medical School.