Roy Parker: The Life of Eukaryotic mRNA

I. mRNA Localization, Translation and Degradation
II. P-bodies and the mRNA Cycle

Part I: mRNA Localization, Translation and Degradation

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Lecture Overview
The control of mRNA production and function is a key aspect of the regulation of gene expression. In the first part of this lecture, I will discuss how in eukaryotic cells, the control of mRNA localization, translation and degradation in the cytoplasm allow for the proper regulation of the amount, duration, and location of protein production. The basic mechanisms of these processes are understood and reveal that the mechanisms of localization, translation, and degradation are interconnected. The unique properties of each mRNA are dictated by its intrinsic interactions with cellular machines, as well as its complement of mRNA specific RNA binding proteins and miRNAs. Strikingly, mRNPs are dynamic and can be modulated by protein modifications as well as by modification of the mRNA itself, thereby providing a diversity of targets for the regulation of mRNA function in response to extracellular signals.  More >>

Speaker Bio
Roy Parker a professor of chemistry and biochemistry and Cech-Leinwand Endowed Chair of Biochemistry at the University of Colorado, Boulder and an Investigator of the Howard Hughes Medical Institute. Prior to joining the University of Colorado in 2012, Parker was a Professor of Molecular and Cellular Biology at the University of Arizona.  More >>

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