Part III: Open Sesame: Cell Entry and Vaccinia Virus
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Viruses are extremely simple and small yet they are responsible for many of the world’s diseases. A virus particle consists of only a genome, a protein coat or capsid, and sometimes a surrounding lipid envelope. To replicate, a virus must successfully enter a host cell, uncoat its genome, and appropriate the host cell machinery to replicate its genome and produce viral proteins. Part 1 of this lecture will discuss ways in which viruses bind to the surface of host cells. Simian Virus 40 which binds to specific cell surface glycolipids, and Human Papilloma Virus-16 which binds to sites on filopodia, are examples of different binding mechanisms. Attachment of viruses to the plasma membrane activates cell signaling resulting in endocytosis of the viral particles. This lecture is appropriate for upper level undergraduate and graduate classes studying virology or endocytosis.
Ari Helenius is from Finland where he studied Biochemistry in the University of Helsinki. During his PhD thesis work, which focussed on the analysis of membrane proteins, he and his colleagues started to work on the biochemical properties of enveloped animal viruses. More >>