David Roos: Genomics and Cell Biology of Apicomplexan Parasites

I. Biology of Apicomplexan Parasites
II. The Apicomplexan Plastid: Something Old, Something New, Something Borrowed, Something Green
IIIA. Designing and Mining Pathogen Genome Databases: From Genes to Drugs and Vaccines
IIIB. Designing and Mining Pathogen Genome Databases: From Genes to Drugs and Vaccines
IIIC. Designing and Mining Pathogen Genome Databases: From Genes to Drugs and Vaccines

Part I: Biology of Apicomplexan Parasites

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Lecture Overview
There are more than 5000 species of single-celled eukaryotes in the biological phylum known as the Apicomplexa, including the parasites responsible for malaria, neurological birth defects, and opportunistic infections associated with HIV/AIDS. These ancient protozoa provide a unique window into the evolution of subcellular organelles that have long fascinated cell biologists. Familiar features help to elucidate the origins, functions and design parameters for the secretory pathway, endosymbiotic organelles, the cytoskeleton, and cell cycle control. Conversely, parasite-specific organelles highlight the evolutionary diversity of eukaryotes, and suggest novel targets for treating disease.  More >>

Speaker Bio
David S. Roos is the E. Otis Kendall Professor of Biology at the University of Pennsylvania, and Founding Director of the Penn Genomics Institute. He earned his undergraduate degree at Harvard College, a PhD at The Rockefeller University, and joined the University of Pennsylvania in 1989 after a post-doctoral stint at Stanford University. More >>

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