Part III: Malaria: Drug Development
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This brief set of three lectures gives a very general overview of malaria, the disease and Plasmodium falciparum, the causative agent of the most deadly form. Basic research as well as drug development efforts will also be covered in parts two and three of this series.
Joseph DeRisi, PhD., is currently a professor at UC San Francisco in the department of Biochemistry and Biophysics and a Howard Hughes Medical Institute Investigator. Prior to joining the faculty at UCSF in 1999, Joe was a UC Fellow for approximately one year. During his graduate work at Stanford University in the laboratory of Patrick O. Brown, Joe was one of the early pioneers of DNA microarray technology and whole genome expression profiling and is nationally recognized for his efforts to make this technology accessible and freely available.
He was the lead instructor of the popular annual Cold Spring Harbor Laboratories course "Making and Using cDNA Microarrays." Joe was a Searle Scholar, and is now a Packard Fellow. He was the recipient of the 2001 JPMorgan Chase Health award and the 2004 WIRED RAVE award.
In addition, Joe holds the first Tomkins Chair at UCSF. Most recently, Joe was chosen for a Macarthur award in 2004. Joe has extended his work to the study of infectious diseases, including malaria and viral pathogens.
- Joseph DeRisi iBioEducation: Genome Sequencing for Pathogen Discovery
- David Roos iBioSeminar: Apicomplexan parasites.
- Norma Andrews iBioSeminar: Intracellular parasitism by Trypanosoma cruzi and Leishmania.
- David Botstein iBioSeminar: Fruits of the genome sequence.
- H. Robert Horvitz iBioEducation Discovery Talks: Discovering Programmed Cell Death
Malaria, Parasite Biology, Pathogenesis, and Protection. (1998) Irwin Sherman, ASM Press.
Current Status of Malaria and Potential for Control. RS Phillips. (2001) Clinical Microbiology Reviews.
Malaria, Molecular Approaches. (2005) Irwin Sherman. ASM Press.
Bozdech et al. The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum. PLoS Biology (2003).
Madrid et al. Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum. J. Med. Chem 2006.
Weisman et al. Searching for New Antimalarial Therapeutics amongst Known Drugs. Chem. Biol. Drug Des 2006.