Part III: Stochasticity and Cell Fate
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How do simple cells differentiate, assemble into communities, and cope with change? Losick's seminar addresses these questions in the spore-forming bacterium Bacillus subtilis.
Part I is an overview of how B. subtilis makes a spore.
Part II presents research on the capacity of B. subtilis cells to form architecturally complex communities.
Part III presents research showing that B. subtilis uses a bet hedging strategy for coping with uncertainty.
Richard Losick is a Howard Hughes Medical Institute Professor, the Maria Moors Cabot Professor of Biology, and a Harvard College Professor. He received his B.A. from Princeton University in 1965 and his Ph.D. from MIT in 1969. He was elected to the Harvard Society of Fellows as a Junior Fellow in 1969, and he joined the faculty of Harvard University in 1972. He is a past chairman of the Department of Molecular and Cellular Biology and the Department of Cellular and Developmental Biology. He teaches the introductory course on molecular biology at Harvard College, and is Head Tutor for the undergraduate concentration in Biochemical Sciences.
He is a member of the National Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, a Fellow of the American Association for the Advancement of Science, a Fellow of the American Academy of Microbiology, and a former Visiting Scholar of the Phi Beta Kappa Society. He is the 2007 winner of the Selman A. Waksman Award of the National Academy of Sciences.
- Bonnie Bassler iBioEducation Lecture: Tiny conspiracies
- Richard Losick Short Clip: Sporulation
- Bonnie Bassler iBioSeminar: Cell-cell communication in bacteria
- Nicole King iBioSeminar: Choanoflagellates and the Origin of Animal Multicellularity
- Lucy Shapiro iBioSeminar: The dynamic bacterial cell
Bassler, B. and Losick, R. Bacterially speaking. Cell 125: 237-246 (2006).
Ben-Yehuda, S., Rudner, D. and Losick, R. RacA, a Bacterial Protein that Anchors Chromosomes to the Cell Poles. Science 299:532-536 (2003).
Rudner, D. Z. and Losick, R. A sporulation membrane protein tethers the pro-sigmaK processing enzyme to its inhibitor and dictates its subcellular localization. Genes & Development 16: 1007-1018 (2002).
Ben-Yehuda, S. and Losick, R. Asymmetric Cell Division in B. subtilis Involves a Spiral-like Intermediate of the Cytokinetic Protein FtsZ. Cell 109:257-266 (2002).
Rudner, D. Z. and Losick, R. Morphological Coupling in Development: Lessons from Prokaryotes. Developmental Cell 1:733-742 (2001).
Arigoni, F., Pogliano, K., Webb, C.D., Stragier, P., and Losick, R. Localization of protein implicated in establishment of cell type to sites of asymmetric division. Science 270:637-640 (1995).
Vlamakis, H., Aguilar, C., Losick, R., Kolter, R. Control of cell fate by the formation of an architecturally complex bacterial community. Genes & Development 22:945-953. (2008).
Chu, F., Kearns, D.B., McLoon, A., Chai, Y., Kolter, R., and Losick R. A novel regulatory protein governing biofilm formation in Bacillus subtilis. Molecular Microbiol. 68:1117-1127. (2008).
Aguilar C, Vlamakis H, Losick R, Kolter R. Thinking about Bacillus subtilis as a multicellular organism. Current Opinion in Microbiology 10:638-643(2007).
Losick, R. and Desplan, C. Stochasticity and Cell Fate. Science 320:65-68. (2008).
Dubnau, D. and Losick, R. Bistability in bacteria. Molecular Microbiol., 61:564-572 (2006).
Kearns, D.B. and Losick R. Cell population heterogeneity during growth of Bacillus subtilis. Genes & Development 19:3083-3094 (2005).