Dr. David Bikard’s lab focuses on engineering bacteria with CRISPR to combat microbial pathogens. In this video, he introduces the historical context for using CRISPR in bacteria and then delves into two CRISPR technologies being developed by his lab. Part of his lab is using CRISPR/Cas9 to eliminate antibiotic resistance in bacterial populations. His group is also optimizing a catalytically dead Cas9 (dCas9) to modulate levels of CRISPR-induced transcriptional repression and use it in pooled high throughput screens for gene function.
Dr. David Bikard is the head of the Synthetic Biology Group at the Institut Pasteur in Paris, France. Originally trained in engineering at AgroParisTech, he later received his Masters and PhD from Paris Diderot University for his work with the Institut Pasteur on the intergron bacterial recombination system. He began working with CRISPR during his… Continue Reading