Dr. Busby gives an overview of the function and regulation of bacterial RNA polymerase. The distribution of RNA polymerase between genes is determined by interactions between RNA polymerase sigma factor, promoter sequences and activating or repressing transcription factors. By engineering additional activators into E. coli and changing where they bind to DNA, Busby and colleagues have been able to alter the regulation of bacterial RNA polymerase on specific transcription units.
Steve Busby is a Professor and Head of the School of Biosciences at the University of Birmingham, where his work focuses on understanding the mechanisms that control gene expression in bacteria. His lab has made fundamental contributions to the understanding of transcription factor activity and promoter recognition by RNA polymerase. Busby is a Fellow of… Continue Reading