Michael Rosen argues that we have considerable insight into how cellular structures are formed at the smallest and largest scales (e.g., proteins and organelles, respectively). However, we know little about cell organization of intermediate-sized structures, such as cellular bodies and membrane puncta, which exist at the micron length scale. He considers the need for new tools, approaches, and ways of thinking to investigate the mechanisms of these structures and understand their functionality.
Michael Rosen is Chair of the Department of Biophysics at University of Texas Southwestern and an Investigator of the Howard Hughes Medical Institute. He studies the assembly and disassembly of actin filaments, a major component of the cytoskeletal network in cells, and focuses on understanding how these filaments organize into higher-order assemblies. Continue Reading