Jennifer Lippincott-Schwartz explores the function of lipids and cholesterol in regulating the secretory pathway, the steps by which newly synthesized proteins are processed and shuttled from the endoplasmic reticulum to the Golgi to the plasma membrane. The composition of membrane lipids and cholesterol changes across these three main compartments. How is the lipids and cholesterol gradient generated, and does it play a role in protein trafficking and membrane organization?
Dr. Lippincott-Schwartz is Chief of the Section on Organelle Biology in the Cell Biology and Metabolism branch of the National Institutes of Health. Using a variety of fluorescent imaging techniques in live cells, Dr. Lippincott-Schwartz and her lab study dynamic protein interactions within cells, in real time and space. Her studies span a range of… Continue Reading