Resources for Engineering Life Flipped Course

How did life evolve? How can we understand the principles of biological systems to create new proteins, chemicals, biological structures, cells and tissues? Find the answers to these questions in this course designed by Drs. Ron Vale and James Fraser at UCSF for first- and second-year graduate students.

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Intro to Engineering Life Flipped Course

Title	Video	Concepts	Duration	Video Downloads	Transcript	PDF Resources (Educators Only)
Session 1: Origins of Life: Protocells and Non-Enzymatic Template-Directed RNA Synthesis What is the origin of life on Earth? Jack Szostak describes the chemistry that may have allowed life to first evolve. With: Jack Szostak Share this session with your students						All Course Materials for this Session (Educators only) – Created by Kelsey Hass
The Origin of Cellular Life on Earth	Watch on iBio Watch on YouTube	Emergence of life, conditions that support life, self-replicating protocell	54:40	Hi-Res Subtitled: English Russian Spanish	View Transcript
Protocell Membranes	Watch on iBio Watch on YouTube	Components of a simple protocell	40:42	Hi-Res Subtitled: English Spanish	View Transcript
Non-Enzymatic Copying of Nucleic Acid Templates	Watch on iBio Watch on YouTube	Chemical replication of nucleic acid	53:51	Hi-Res Subtitled: English Spanish	View Transcript
Session 2: Microbial Diversity and Evolution Dianne Newman gives an overview of the immense microbial diversity found on Earth and the importance of microbes to evolution and environmental health. With: Dianne Newman Share this session with your students						All Course Materials for this Session (Educators only) – Created by Jasper Williams
Microbial Diversity and Evolution	Watch on iBio Watch on YouTube	Microbial diversity, fossilized and modern microbes, metabolism evolution in microbes, rRNA phylogenetic tree of bacteria	53:43	Hi-Res Subtitled: English Spanish	View Transcript
Interpreting Molecular Fossils of Oxygenic Photosynthesis	Watch on iBio Watch on YouTube	Evolution of oxygenic photosynthesis	40:21	Hi-Res Subtitled: English Spanish	View Transcript
Session 3: Protein Design David Baker talks about crowdsourcing science and how Foldit, an interactive protein folding program, allows individuals to predict the most likely fold for a protein. With: David Baker Share this session with your students						All Course Materials for this Session (Educators only) – Created by Aditya Anand and Lynn Wang
Introduction to Protein Design	Watch on iBio Watch on YouTube	Protein 3D structural predictions, determining the structure of a sequence of amino acids, Rosetta@Home	21:21	Hi-Res Low-Res	View Transcript
Design of New Protein Functions	Watch on iBio Watch on YouTube	Designing new protein functions	26:47	Hi-Res Low-Res	View Transcript
Session 4: An Introduction to Polyketide Assembly Lines Polyketide antibiotics include many of the most commonly used antibiotics in medicine today. Dr. Chaitan Khosla describes the modular enzymes that synthesize these antibiotics in a manner much like an assembly line. With: Chaitan Khosla Share this session with your students						All Course Materials for this Session (Educators only) – Created by Becky Anderson and Ben Barsi-Rhyne
An Introduction to Polyketide Assembly Lines	Watch on iBio Watch on YouTube	Polyketide antibiotics (e.g. erythromycin & rapamycin) synthesis	35:45	Hi-Res Low-Res Subtitled: English	View Transcript
Dissecting Polyketide Assembly Lines	Watch on iBio Watch on YouTube	Studying polyketide assembly line enzymes in bacteria, producing novel polyketide products	28:30	Hi-Res Low-Res Subtitled: English	View Transcript
Vectorial Specificity of Assembly Lines	Watch on iBio Watch on YouTube	Vectorial specificity in polyketide synthesis pathway	29:36	Hi-Res Low-Res Subtitled: English	View Transcript
Session 5: Nanofabrication via Structural DNA In this session about nanofabrication and DNA origami, William Shih describes how DNA can be used as a building material to construct nanoscale objects. With: William Shih Share this session with your students						All Course Materials for this Session (Educators only) – Created by Karen Cheng
Nanofabrication via DNA Origami	Watch on iBio Watch on YouTube	Using DNA to make nanoscale objects, DNA origami	39:34	Hi-Res Low-Res Subtitled: English	View Transcript
Nanofabrication via DNA Single Stranded Bricks	Watch on iBio Watch on YouTube	Using DNA bricks to make 3D nanostructures	33:37	Hi-Res Low-Res Subtitled: English	View Transcript
DNA-Nanostructure Tools	Watch on iBio Watch on YouTube	Uses of DNA-nanostructures	40:40	Hi-Res Low-Res Subtitled: English	View Transcript
Session 6: Synthetic Biology and Metabolic Engineering Kristala L. J. Prather explains that synthetic biology involves applying engineering principles to biological systems to build “biological machines." With: Kristala Prather Share this session with your students						All Course Materials for this Session (Educators only) – Created by Tess Veuthey
Introduction to Synthetic Biology and Metabolic Engineering	Watch on iBio Watch on YouTube	Introduction to synthetic biology, synthetic DNA	26:11	Hi-Res Low-Res Subtitled: English	View Transcript
Teaching an Old Bacterium New Tricks	Watch on iBio Watch on YouTube	Engineering the production of glucaric acid from glucose in E. Coli	38:36	Hi-Res Low-Res Subtitled: English	View Transcript
Session 7: Tissue Engineering Sangeeta Bhatia explains when and why tissues are engineered and describes the challenges of tissue engineering. With: Sangeeta Bhatia Share this session with your students						All Course Materials for this Session (Educators only) – Created by Karina Perlaza and Brian Yang
Engineering Tissue Replacements	Watch on iBio Watch on YouTube	Introduction and challenges of tissue engineering	39:03	Hi-Res Subtitled: English	View Transcript
Microscale Liver Tissue Engineering	Watch on iBio Watch on YouTube	Developing an implantable, engineered liver	29:59	Hi-Res Subtitled: English	View Transcript
Session 8: Controlled Drug Release Technology Bob Langer gives an overview of controlled drug release technologies. With: Robert Langer Share this session with your students						All Course Materials for this Session (Educators only) – Created by Valentina Garcia and Lindsay Osso
Controlled Drug Release Technology	Watch on iBio Watch on YouTube	Plasma drug levels, optimizing drug release, drug release technologies	37:44	Hi-Res Low-Res Subtitled: English	View Transcript
Drug Delivery Technology: Present and Future	Watch on iBio Watch on YouTube	Drug release technologies, targeted drug delivery, drug delivery using microchips	35:11	Hi-Res Low-Res Subtitled: English	View Transcript
Biomaterials for Drug Delivery Systems and Tissue Engineering	Watch on iBio Watch on YouTube	Drug delivery and medical devices	26:50	Hi-Res Low-Res Subtitled: English	View Transcript
Session 9: Advancing the Treatment of Retinal Diseases Robert Bhisitkul and Tejal Desai describe how treatment for retinal diseases and vision loss may be improved by efforts to develop implantable devices for drug delivery. With: Robert Bhisitkul, Tejal Desai Share this session with your students						All Course Materials for this Session (Educators only) – Created by Valentina Garcia and Lindsay Osso
Advancing the Treatment of Retinal Diseases	Watch on iBio Watch on YouTube	Retinal diseases, vision loss, implantable devices for drug delivery, age-related macular degeneration	35:16	Hi-Res Low-Res Subtitled: English	View Transcript