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Home » Educator Resources » Flipped Courses » Engineering Life Flipped Course
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Resources for Engineering Life Flipped Course

How did life evolve? How can we understand the principles of biological systems to create new proteins, chemicals, biological structures, cells and tissues? Find the answers to these questions in this course designed by Drs. Ron Vale and James Fraser at UCSF for first- and second-year graduate students.

To access the curricula you must register as an educator. If you are already registered, then log in here.

Intro to Engineering Life Flipped Course

Title Video Concepts Duration Video Downloads Transcript PDF Resources
(Educators Only)
Session 1: Origins of Life: Protocells and Non-Enzymatic Template-Directed RNA Synthesis

What is the origin of life on Earth? Jack Szostak describes the chemistry that may have allowed life to first evolve.

With: Jack Szostak

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All Course Materials for this Session (Educators only) – Created by Kelsey Hass

The Origin of Cellular Life on Earth The Origin of Cellular Life on Earth
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Emergence of life, conditions that support life, self-replicating protocell 54:40 Hi-Res

Subtitled:

  • English
  • Russian
  • Spanish
View Transcript
Protocell Membranes Protocell Membranes
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Components of a simple protocell 40:42 Hi-Res

Subtitled:

  • English
  • Spanish
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Non-Enzymatic Copying of Nucleic Acid Templates Non-Enzymatic Copying of Nucleic Acid Templates
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Chemical replication of nucleic acid 53:51 Hi-Res

Subtitled:

  • English
  • Spanish
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Session 2: Microbial Diversity and Evolution

Dianne Newman gives an overview of the immense microbial diversity found on Earth and the importance of microbes to evolution and environmental health.

With: Dianne Newman

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All Course Materials for this Session (Educators only) – Created by Jasper Williams

Microbial Diversity and Evolution Microbial Diversity and Evolution
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Microbial diversity, fossilized and modern microbes, metabolism evolution in microbes, rRNA phylogenetic tree of bacteria 53:43 Hi-Res

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  • English
  • Spanish
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Interpreting Molecular Fossils of Oxygenic Photosynthesis Interpreting Molecular Fossils of Oxygenic Photosynthesis
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Evolution of oxygenic photosynthesis 40:21 Hi-Res

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  • English
  • Spanish
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Session 3: Protein Design

David Baker talks about crowdsourcing science and how Foldit, an interactive protein folding program, allows individuals to predict the most likely fold for a protein.

With: David Baker

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All Course Materials for this Session (Educators only) – Created by Aditya Anand and Lynn Wang

Introduction to Protein Design Introduction to Protein Design
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Protein 3D structural predictions, determining the structure of a sequence of amino acids, Rosetta@Home 21:21 Hi-Res Low-Res View Transcript
Design of New Protein Functions Design of New Protein Functions
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Designing new protein functions 26:47 Hi-Res Low-Res View Transcript
Session 4: An Introduction to Polyketide Assembly Lines

Polyketide antibiotics include many of the most commonly used antibiotics in medicine today. Dr. Chaitan Khosla describes the modular enzymes that synthesize these antibiotics in a manner much like an assembly line.

With: Chaitan Khosla

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All Course Materials for this Session (Educators only) – Created by Becky Anderson and Ben Barsi-Rhyne

An Introduction to Polyketide Assembly Lines An Introduction to Polyketide Assembly Lines
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Polyketide antibiotics (e.g. erythromycin & rapamycin) synthesis 35:45 Hi-Res Low-Res

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  • English
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Dissecting Polyketide Assembly Lines Dissecting Polyketide Assembly Lines
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Studying polyketide assembly line enzymes in bacteria, producing novel polyketide products 28:30 Hi-Res Low-Res

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  • English
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Vectorial Specificity of Assembly Lines Vectorial Specificity of Assembly Lines
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Vectorial specificity in polyketide synthesis pathway 29:36 Hi-Res Low-Res

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Session 5: Nanofabrication via Structural DNA

In this session about nanofabrication and DNA origami, William Shih describes how DNA can be used as a building material to construct nanoscale objects.

With: William Shih

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All Course Materials for this Session (Educators only) – Created by Karen Cheng

Nanofabrication via DNA Origami Nanofabrication via DNA Origami
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Using DNA to make nanoscale objects, DNA origami 39:34 Hi-Res Low-Res

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  • English
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Nanofabrication via DNA Single Stranded Bricks Nanofabrication via DNA Single Stranded Bricks
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Using DNA bricks to make 3D nanostructures 33:37 Hi-Res Low-Res

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  • English
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DNA-Nanostructure Tools DNA-Nanostructure Tools
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Uses of DNA-nanostructures 40:40 Hi-Res Low-Res

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Session 6: Synthetic Biology and Metabolic Engineering

Kristala L. J. Prather explains that synthetic biology involves applying engineering principles to biological systems to build “biological machines."

With: Kristala Prather

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All Course Materials for this Session (Educators only) – Created by Tess Veuthey

Introduction to Synthetic Biology and Metabolic Engineering Introduction to Synthetic Biology and Metabolic Engineering
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Introduction to synthetic biology, synthetic DNA 26:11 Hi-Res Low-Res

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Teaching an Old Bacterium New Tricks Teaching an Old Bacterium New Tricks
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Engineering the production of glucaric acid from glucose in E. Coli 38:36 Hi-Res Low-Res

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  • English
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Session 7: Tissue Engineering

Sangeeta Bhatia explains when and why tissues are engineered and describes the challenges of tissue engineering.

With: Sangeeta Bhatia

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All Course Materials for this Session (Educators only) – Created by Karina Perlaza and Brian Yang

Engineering Tissue Replacements Engineering Tissue Replacements
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Introduction and challenges of tissue engineering 39:03 Hi-Res

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  • English
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Microscale Liver Tissue Engineering Microscale Liver Tissue Engineering
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Developing an implantable, engineered liver 29:59 Hi-Res

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  • English
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Session 8: Controlled Drug Release Technology

Bob Langer gives an overview of controlled drug release technologies.

With: Robert Langer

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All Course Materials for this Session (Educators only) – Created by Valentina Garcia and Lindsay Osso

Controlled Drug Release Technology Controlled Drug Release Technology
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Plasma drug levels, optimizing drug release, drug release technologies 37:44 Hi-Res Low-Res

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Drug Delivery Technology: Present and Future Drug Delivery Technology: Present and Future
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Drug release technologies, targeted drug delivery, drug delivery using microchips 35:11 Hi-Res Low-Res

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  • English
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Biomaterials for Drug Delivery Systems and Tissue Engineering Biomaterials for Drug Delivery Systems and Tissue Engineering
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Drug delivery and medical devices 26:50 Hi-Res Low-Res

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  • English
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Session 9: Advancing the Treatment of Retinal Diseases

Robert Bhisitkul and Tejal Desai describe how treatment for retinal diseases and vision loss may be improved by efforts to develop implantable devices for drug delivery.

With: Robert Bhisitkul, Tejal Desai

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All Course Materials for this Session (Educators only) – Created by Valentina Garcia and Lindsay Osso

Advancing the Treatment of Retinal Diseases Advancing the Treatment of Retinal Diseases
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Retinal diseases, vision loss, implantable devices for drug delivery, age-related macular degeneration 35:16 Hi-Res Low-Res

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  • English
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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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