Michael Rosbash tells the story of how a collaboration with friend Jeff Hall led to the discovery of the genetic mechanisms that regulate circadian rhythms. Circadian rhythms are the physiological and behavioral changes, such as sleep and wakefulness, which occur in response to a 24-hour cycle of light and darkness. Using Drosophila as a model, Rosbash and Hall cloned the circadian timekeeping gene called period. They later demonstrated that period blocks its own transcription through an oscillating negative feedback loop.
Michael Rosbash is Professor of Biology at Brandeis University and Investigator of the Howard Hughes Medical Institute. Rosbash uses genetics to understand the underlying mechanisms of circadian rhythms. In 1984, Rosbash, along with collaborator Jeff Hall, cloned the period gene in Drosophila, which led them to discover the transcriptional negative feedback loop of circadian clocks… Continue Reading