Some people harbor deleterious mutations in disease-relevant genes, yet they are completely healthy. How are scientists trying to understand these so-called ‘genetic superheros’? In this Share Your Research talk, Dr. Mohamed El-Brolosy describes his thesis research in the model organism zebrafish. Dr. El-Brolosy found that genetic compensation to deleterious mutations relies on degradation of the mutant mRNA, which triggers upregulation of compensatory genes in a homology-dependent manner. These findings can inform strategies to better understand and treat genetic diseases, many of which have limited therapeutic options.
Mohamed El-Brolosy researches genetic compensation and how organisms adapt to mutations, and has authored numerous highly cited papers on the subject. He performed his thesis research with Dr. Didier Stainier at the Max Planck Institute for Heart & Lung Research. He is currently a junior fellow at the Harvard society of fellows. Follow him on… Continue Reading