Dr. J. Michael Bishop tells us the story of his Nobel Prize-winning discovery of cellular proto-oncogenes. Bishop was studying how the Rous Sarcoma Virus (RSV) causes cancer in chickens by expressing the viral protein called Src. Together with Dr. Harold Varmus, Bishop discovered that the chicken genome normally expresses a homolog of the viral Src protein that they called cellular-Src (c-Src). This finding led them to the remarkable conclusion that RSV had incorporated a mutated oncogene version of the normal chicken c-Src protein, and, provided the first evidence that mutations in our own genes can be linked to cancer development.
Learn more about this and other discoveries at The Explorer’s Guide to Biology (XBio).
Dr. Bishop received his undergraduate degree from Gettysburg College and his M.D. from Harvard Medical School. Harvard provided Bishop with his first research experience and introduced him to the study of animal viruses. Bishop completed his clinical training at Massachusetts General Hospital and pursued a research fellowship at the National Institutes of Health. In 1968,… Continue Reading