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Research Paper Discussed in this Talk
Cox JS, Walter P. (1996). A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell, Nov 1;87(3):391-404.
Educator Resources (Educators only)
These questions and answers were designed to link the iBiology video to the research paper and for use as a classroom activity.
Prepared by Dr. Yi Liu.
About this Talk
Proteins that are secreted from the cell or inserted into the plasma membrane transit through the endoplasmic reticulum, where they are properly folded and assembled and may undergo post-translational modification. Walter tells the story of the exciting discovery made in his lab of the “unfolded protein response”, a feedback pathway that ensures that the cell makes enough ER to properly modify all the secreted proteins in the cell.
This video is located in: iBioMagazine Issue 1
About the Speaker
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- Arthur Horwich iBioSeminar: Chaperone-Assisted Protein Folding
- Susan Taylor iBioSeminar: Protein Phosphorylation
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