Synthetic Biology and Escherichia Coli
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Dr. Busby gives an overview of the function and regulation of bacterial RNA polymerase. The distribution of RNA polymerase between genes is determined by interactions between RNA polymerase sigma factor, promoter sequences and activating or repressing transcription factors. By engineering additional activators into E. coli and changing where they bind to DNA, Busby and colleagues have been able to regulate the activity of polymerase on specific transcription units.
About the Speaker: Steve Busby
Steve Busby is a Professor and Head of the School of Biosciences at the University of Birmingham, where his work focuses on understanding the mechanisms that control gene expression in bacteria. His lab has made fundamental contributions to the understanding of transcription factor activity and promoter recognition by RNA polymerase. Busby is a Fellow of the Royal Society.