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About this Talk
While postdoctoral fellows at the NIH, Joe Goldstein and Michael Brown were presented with a young patient with familial hypercholesterolemia (FH), a disease characterized by high LDL cholesterol and atherosclerosis. Scientific curiosity along with a desire to help these patients led Brown and Goldstein to dedicate themselves to understanding the biological basis for FH. This video by Youreka Science describes the experiments that led to the Nobel Prize winning discovery of LDL receptors and the mechanism of receptor-mediated endocytosis.
Related Resources for this Video
- Research Paper Discussed in this Talk: Goldstein, J.L. & Brown, M.S. 1973. Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. PNAS 70: 2804-8.
- Michael Brown and Joseph Goldstein Discovery Talk: The Molecular Basis of Familial Hypercholesterolemia
About Youreka Science
Youreka Science was created by Florie Mar, a cancer researcher from UCSF. While teaching 5th graders about the structure of a cell, Mar realized the importance of incorporating scientific findings into classroom in an easy-to-understand way. From that she started creating whiteboard drawings that explained recent papers in the scientific literature to the general public. Mar has created over twenty videos about the latest scientific experiments and is now joined by Alex Olson to produce more fun and engaging videos. Learn more at http://yourekascience.org/
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