During their 20-year friendship, Betzig and Hess worked together and separately, in academia and industry, before eventually joining forces to develop the first super-high-resolution PALM microscope. They tell us the story of this journey and emphasize how their unusual and varied backgrounds provided the skills to complete the project.
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Research Paper Discussed in this Talk
Betzig E, Patterson GH, Sougrat R, Lindwasser OW, Olenych S, Bonifacino JS, Davidson MW, Lippincott-Schwartz J, Hess HF. Imaging intracellular fluorescent proteins at nanometer resolution. Science. 2006 Sep 15;313(5793):1642-5.
Educator Resources (Educators only)
These questions and answers were designed to link the iBiology video to the research paper and for use as a classroom activity.
Prepared by Dr. Kassandra Ori-McKenney.
About the Speaker
Both Harald Hess and Eric Betzig are Group Leaders at The Howard Hughes Medical Institute’s Janelia Farm Research Campus. Together and individually, they continue to develop new imaging methods that can be used to peer more and more deeply into tissues and cells. Eric Betzig was awarded the 2014 Nobel Prize in Chemistry for his role in developing super-resolution microscopy.
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