I. Yeast Sex: An Introduction
II. How to Shmoo and Find a Mate
Part I: Yeast Sex: An Introduction
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Murray begins his talk by explaining why he studies sex in yeast not humans. He describes the yeast life cycle including the decision to bud in the absence of a mate, or to shmoo and mate in the presence of yeast of the correct mating type. In either case, the cells must switch from uniform to non-uniform or polarized growth. Mating cells must also recognize a chemical signal and move towards a target cell. Murray explains the molecular details known to underlie the response to the chemical signal. In Part 2, Murray describes experiments done in his lab to learn more about mating in yeast. These experiments provide an example of how models are proposed, how experiments are designed to discriminate between the models and how further experiments may be needed to address questions raised by the models.
Andrew Murray received his undergraduate education at Clare College, Cambridge and his Ph.D. from Harvard Medical School. He then spent 15 years at the University of California, San Francisco as a post-doctoral fellow and faculty member before returning to Harvard. Currently, Murray is a Professor of Molecular and Cellular Biology and co-director of the FAS Center for Systems Biology at Harvard University. Murray’s lab uses budding yeast to investigate the general principles of how cells transmit genetic information during cell division and mating and how they evolve in response to selective pressure. Members of his lab use math and physics, as well as biology, to test possible models.
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A brief history of error. Murray AW. Nat Cell Biol. 2011 Oct 3;13(10):1178-82.
Chemical gradients and chemotropism in yeast. Arkowitz RA. Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a001958.
Symmetry breaking in the life cycle of the budding yeast. Slaughter BD, Smith SE, Li R. Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a003384.
Positive-feedback loops as a flexible biological module. Ingolia NT, Murray AW. Curr Biol. 2007 Apr 17;17(8):668-77.