I. Engineering Tissue Replacements
II. Microscale Liver Tissue Engineering
Part I: Engineering Tissue Replacements
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The concept of engineering tissues that are part cell and part synthetic material was proposed nearly 20 years ago. Bhatia explains why one would choose to use an engineered tissue and the challenges of engineering a tissue that reproduces the micro-architecture of tissue in vivo. She goes on to describe how the ingredients and the methods of fabrication of a hybrid tissue are chosen.
In the second part of her talk, Bhatia tells us about research from her lab and others to develop an implantable, engineered liver. She explains the challenges of co-culturing hepatocytes and the supporting cells necessary to keep the hepatocytes functional. Her lab has successfully engineered microscale human livers that are showing promise as a mechanism to identify drugs that are toxic to the liver and to study viruses and parasites that attack the liver.
Sangeeta Bhatia received her Sc.B. in biomedical engineering from Brown University, her M.D. from Harvard Medical School and her Ph.D. from MIT. She is currently Professor of Health Sciences and Technology and of Electrical and Computer Science at MIT and a Howard Hughes Medical Institute Investigator. Research in her lab is focused on using micro- and nano-technologies for tissue repair and regeneration with particular emphasis on therapies for liver disease.
Dr. Bhatia has worked in the biotechnology industry and holds a number of patents and she has co-authored two textbooks. She has received many awards including a David and Lucille Packard Fellowship, a Global Indus Technovator Award and she has been named one of Massachusetts’ “Women to Watch”.
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Palsson B.O. and Bhatia S.N. (2003). Tissue Engineering. Prentice Hall.