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Injecting adult stem cells into the bloodstream could help regenerate tissue damaged by heart attacks. For this to happen, circulating stem cells need to exit blood vessels and reach the damaged tissue. While scientists knew that circulating stem cells are able to exit the bloodstream, how they did it was a mystery. In this lecture, Tyler Allen describes angiopellosis, a new way for circulating stem cells exit blood vessels when injected into the blood for therapies.
Tyler Allen received his bachelor's degrees in Biology and Plant Biology from North Carolina (NC) State University. Upon graduation, Allen joined the laboratory of regenerative medicine expert, Dr. Ke Cheng, as a PhD student at NC State's College of Veterinary Medicine. Allen's research involves understanding how adult stem cells exit blood vessels, when injected into the blood for therapies. He uses transgenic, microscopic, and molecular biology tools to dissect how cells escape the circulation and reach damaged tissue. In his free time, Allen enjoys weightlifting, playing piano, and tasting different types of bread (croissants are his favorite).
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Allen,T. A., et al. (2016) Angiopellosis as an Alternative Mechanism of Cell Extravasation. Stem Cells, 35: 170–180.