I. Fruits of the Genome Sequences
II. Connecting Growth Control and Stress Response
Part I: Fruits of the Genome Sequences
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In Part 1 of his lecture, Dr. Botstein gives an overview of the benefits for science and society derived from sequencing the genomes of multiple organisms, including humans. The sequences show that many genes have been conserved during evolution; a finding that allows scientists to study simple organisms such as yeast and relate their findings to mammalian biology. In addition, mining genome sequences has identified numerous genes involved in human disease, in some cases resulting in improved screening and treatment.
In his second lecture, Botstein describes experiments done in his lab studying, in yeast, the coordination of growth rate, stress response, metabolism and cell division. Using innovative methods to color code and cluster numerical data from DNA hybridization experiments allows the identification of genes involved in regulating how fast cells grow under different conditions.
David Botstein has been the Director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University since 2003. (For more information on this institute and its unique program, see Botstein’s iBioMagazine talk). Prior to this, Botstein was a professor at the Massachusetts Institute of Technology and Stanford University. He also worked in the biotechnology industry as Vice President-Science at Genentech.
Botstein is well known for making breakthroughs in gene mapping and genomic analysis techniques. Currently, his lab works to understand how cellular growth rate is controlled under different environmental conditions.
Botstein is a member of the U.S. National Academy of Sciences and the Institute of Medicine, amongst other honors.
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