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Most microorganisms cannot survive in the hostile acidic environment of the stomach, but somehow Helicobacter pylori calls the stomach its home. Infection with H. pylori can cause stomach ulcers in humans and is a risk factor for the development of stomach cancer, the third-leading cause of cancer deaths worldwide. Dr. Julie Huang tells us the story of how H. pylori thrives by navigating towards more neutral environments within the stomach using a chemoreceptor called TlpB. Understanding how H. pylori finds this niche opens new routes for developing novel approaches to preventing stomach ulcers and cancer.
Dr. Julie Huang completed her Bachelor degree at the California Institute of Technology. Given her scientific merits, she was granted a Fulbright scholarship in 2009 to work at the Max Planck Institute for Marine Microbiology in Germany. Afterwards, Huang joined the Microbiology and Immunology Doctoral Program at Stanford University, where she worked with Dr. Manuel Amieva to study how the pathogen H. pylori survives in the stomach. Huang’s interest in outreach led her to become involved in different mentoring initiatives, including co-founding the Stanford First Gen/Low-Income (FLI) Undergraduate Mentoring Program.
- Jayme Dyer Young Scientist Series seminar: Knowing Where to Go: How Cells Drive Without Eyes
- Richard Losick iBioSeminar: Developmental Biology of a Simple Organism
- Lucy Shapiro iBioSeminar: The Dynamic Bacterial Cell
- Dianne Newman iBioSeminar: Microbial Diversity and Evolution
- Christine Jacobs-Wagner iBioSeminar: The spatial organization of bacterial cells
- Stanley Falkow iBioSeminar: Helicobacter pylori and Gastric Cancer
Sigal et al., Helicobacter pylori Activates and Expands Lgr5+ Stem Cells Through Direct Colonization of the Gastric Glands. Gastroenterology (2015) 148, 1392-404
Howitt et al., ChePep controls Helicobacter pylori Infection of the gastric glands and chemotaxis in the Epsilonproteobacteria. MBio (2011) 2(4)
Huang et al., Chemodetection and Destruction of Host Urea Allows Helicobacter pylori to Locate the Epithelium. Cell Host Microbe (2015) 18, 147-56
Amieva & Peek, Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology (2016) 150, 64-78.
Keilberg & Ottemann, How Helicobacter pylori senses, targets and interacts with the gastric epithelium. Environ Microbiol (2016) 18, 791-806