Part IB: Photoreceptors and Image Processing
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In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene.
The second lecture focuses on the photoreceptors that mediate human color vision and the molecular basis for the common inherited anomalies of color vision.
The third lecture describes recent work on the evolution of trichromatic color vision in humans and our primate relatives.
Jeremy Nathans is a Professor in the Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology at the Johns Hopkins University School of Medicine. He is also an Investigator of the Howard Hughes Medical Institute.
He received B.S. degrees in Chemistry and in Life Sciences from the Massachusetts Institute of Technology in 1979, and Ph.D. (in Biochemistry) and M.D. degrees from the Stanford University School of Medicine in 1985 and 1987. After a one-year postdoctoral fellowship at Genentech, he joined the Johns Hopkins faculty in 1988.
Dr. Nathans has received numerous awards for his research and teaching, including the Initiatives in Research Award from the National Academy of Sciences, the Cogan Award from the Association for Research in Vision and Ophthalmology, the Young Investigator Award from the Society for Neuroscience, and the Teacher of the Year Award from the Graduate Student Association at the Johns Hopkins Medical School. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. The principal research interests of the Nathans lab center on two areas: the structure and function of the vertebrate visual system; and pattern formation in development, with a particular focus on signaling through the family of "Frizzled" receptors.
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Jacobs, G.H. (1998) Photopigments and seeing--lessons from natural experiments: the Proctor lecture. Invest. Ophthalmol. Vis. Sci. 39:2204-2216.
Rodieck, R.W. (1998) The First Steps of Seeing. Sunderland, MA: Sinauer Associates. 562 pp.
Nathans, J. (1999) The evolution and physiology of human color vision: insights from molecular genetic studies of visual pigments. Neuron 24:299-312.
Deeb, S.S. (2005) The molecular basis of variation in human color vision. Clin. Genet. 67:369-377.
Luo, D.G, Xue, T., Yau, K.W. (2008) How vision begins: an odyssey. Proc. Natl. Acad. Sci. USA 105:9855-62.
Hecht, S., Shlaer, S., Perinne, M.H. (1942) Energy, quanta, and vision. J. Gen. Physiol. 25:819-840.
Baylor, D.A., Lamb, T.D., Yau, K.W. (1979) Responses of retinal rods to single photons. J. Physiol. 288:613-634.
Baylor, D.A., Matthews, G., Yau, K.W. (1980) Two components of electrical dark noise in toad retinal rod outer segments. J. Physiol. 309:591-621.
Jacobs, G.H., Neitz, M., Deegan, J.F., Neitz, J. (1996) Trichromatic colour vision in New World monkeys. Nature 382:156-158.
Smallwood, P.M., Wang, Y., Nathans, J. (2002) Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes. Proc. Natl. Acad. Sci. USA 99:1008-1011.
Smallwood, P.M., Olveczky, B.P., Williams, G.L., Jacobs, G.H., Reese, B.E., Meister, M., Nathans, J. (2003) Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision. Proc. Natl. Acad. Sci. USA 100:11706-11711.
Olveczky, B.P., Baccus, S.A., Meister, M. (2003) Segregation of object and background motion in the retina. Nature 423:401-408.
Hofer, H., Carroll, J., Neitz, J., Neitz, M., Williams, D.R. (2005) Organization of the human trichromatic cone mosaic. J. Neurosci. 25:9669-9679.
Jacobs, G.H., Williams, G.A., Cahill, H., Nathans, J. (2007) Emergence of novel color vision in mice engineered to express a human cone photopigment. Science 315:1723-1725.