I. Biology of Plant Virus Infection
II. Genetic Engineering for Virus Resistance in Plants: Different Viruses Demand Different Strategies
Part II: Genetic Engineering for Virus Resistance in Plants: Different Viruses Demand Different Strategies
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This seminar describes the cell and molecular biology of plant virus infection. The first lecture will discuss how virus replication centers are set up in plants and how viruses use host cell mechanisms to facilitate cell to cell movement and eventual pathogenesis. The second part of the lecture will relate how this information can be used to produce crops resistant to specific viruses through different biotechnology strategies.
Roger Beachy is the founding president of the Donald Danforth Plant Science Center in St. Louis, Missouri where his research focuses on the cellular and molecular mechanisms of virus disease in plants. Before joining the Danforth Center, Beachy headed the Division of Plant Biology at The Scripps Research Institute in La Jolla from 1991-1998 and he was a member of the Biology Department at Washington University in St. Louis from 1978-1991.
In collaboration with Monsanto Company, Beachy developed a viral-disease resistant tomato- the world's first genetically modified food crop. Beachy has a Ph.D. in plant pathology from Michigan State University and a B.A. from Goshen College.
Beachy has received numerous awards for his research and serves on a number of boards and committees including the International Crops Research Institute for the Semi-Arid Tropics in Hyderabad. Beachy is a member of the U.S. National Academy of Sciences.
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- Roger Beachy Short Clip: Tobacco Mosaic Virus
Beachy, R.N. 1999 Coat-protein-mediated resistance to tobacco mosaic virus:discovery mechanisms and exploitation. Philos Trans R Soc Lond B Biol Sci 354(1383):659-64.
Asurmendi, S., H. Berg, J. Koo, and R.N. Beachy. 2004. Coat protein regulates formation of replication complexes during TMV infection. Proc Natl Acad Sci U S A 101:1415-1420.
Kawakami, S., Y. Watanabe, and R.N. Beachy. 2004. Tobacco mosaic virus infection spreads cell to cell as intact replication complexes. Proc Natl Acad Sci U S A 101:6291-6296.
Bendahmane, M., Chen, I., Asurmendi, S., Bazzini, A.A., Szecsi, J., and Beachy, R. N. 2007 Coat protein-mediated resistance to TMV infection of Nicotiana tabacum involves multiple modes of interference by coat protein. Virology 366(1):107-16.
Asurmendi, S., Berg, R.H., Smith, T.J., Bendahmane, M., and Beachy, R.N. 2007 Aggregation of TMV CP plays a role in CP functions and in coat-protein-mediated resistance. Virology 366(1):98-106.