I. Advances in Controlled Drug Release Technology: An Overview
II. Drug Delivery Technology: Present and Future
III. Biomaterials for Drug Delivery Systems and Tissue Engineering
Part I: Advances in Controlled Drug Release Technology: An Overview
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The traditional way of taking a drug, such as a pill or injection, often results in plasma drug levels that cycle between too high and too low. To better maintain drug levels in the effective range, scientists have developed a variety of systems that release drugs at a steady rate for days or even years. In his first talk, Bob Langer gives an overview of many of these controlled release technologies, including polymer and pump systems.
Langer begins Part 2 with the story of how he became interested in drug release technologies, which is also a story of the power of perseverance. As a post-doc with Judah Folkman, and after much trial and error, Langer developed a polymer system that provided a slow and constant release of an anti-angiogenesis factor. Initially, his results were met with skepticism, by both scientists and the patent office. Today, many, many companies have developed peptide delivery systems based on that original work. Langer also describes ongoing research in areas such as targeted drug delivery and externally controlled microchips designed for drug delivery.
In Part 3, Langer focuses on the materials used in drug delivery and medical devices. Many of the original materials used in medicine were adapted from completely unrelated uses and often generated their own problems. Langer describes work by his lab and others to make polymers designed for specific medical uses. For instance, a porous polymer can be shaped into an ear or nose and act as a scaffold onto which a patient’s cells can be seeded to grow a new structure. Different polymers have been successfully used as scaffolds to grow new blood vessels or artificial skin for burn victims.
Robert Langer is the David H. Koch Institute Professor at the Massachusetts Institute of Technology. Research in Langer’s lab focuses on the development of polymers for use in drug delivery devices that will release molecules such as drugs, proteins, RNA or DNA at controlled rates and for extended periods of time. His lab also is working on methods to create new tissues such as cartilage, skin and liver for use in medicine.
Langer has written over 1250 articles and has over 1000 patents; he is the most cited engineer ever. He has been honored with numerous awards including being one of only seven people to receive both the US National Medal of Science and the National Medal of Technology and Innovation. He is also one of only a few people to be elected to the US National Academy of Sciences, Institute of Medicine and National Academy of Engineering. He is the only engineer to win the Gairdner Foundation International Award. In 2014, Langer received the Breakthrough Prize in Life Sciences and the Kyoto Prize.
Langer received his BS in Chemical Engineering from Cornell University and his ScD in Chemical Engineering from MIT.
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Langer R. (2013) Biomaterials and biotechnology: from the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering. J Biomed Mater Res A. Sep;101(9):2449-55. PMID: 23723136
Langer R. (1998) Drug delivery and targeting. Nature. Apr 30;392(6679 Suppl):5-10. PMID: 9579855
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Mitragotri S, Burke PA, Langer R. (2014) Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov. Sep;13(9):655-72. PMID: 25103255
Whitehead KA1, Langer R, Anderson DG. (2009) Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov. Feb;8(2):129-38. PMID: 19180106