When he was a graduate student, Dr. Ruslan Medzhitov read a theory written by Dr. Charles Janeway that foresaw the existence of a set of receptors that would directly detect pathogens and signal to T- and B-cells to generate an immune response (adaptive immunity). Medzhitov was determined to find such receptors! In this discovery talk, Dr. Ruslan Medzhitov provides a historical perspective that frames his involvement in the discovery of Toll-Like Receptors. By following the clue that NF-kB was involved in the immune response, he searched for receptors, like Toll, that had the capacity to activate NF-kB.
Dr. Ruslan Medzhitov is a Sterling Professor of immunology at Yale School of Medicine and a Howard Hughes Medical Institute investigator. His laboratory studies the signals that initiate and control the process of inflammation, allergic reaction, and immune response. His laboratory also studies tissue biology, and the communication circuits that help to establish stable cellular… Continue Reading