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Darkfield and Phase Contrast Microscopy

Ted Salmon describes the principles of dark field and phase contrast microscopy, two ways of generating contrast in a specimen which may be hard to see by bright field. (Talk recorded in July 2012)

Darkfield and Phase Contrast Microscopy (Edward Salmon)
Audience:
  • Researcher
Duration: 34:14

Fluorescence Microscopy

Nico Stuurman describes how fluorescence microscopy is a very powerful tool in Cell Biology research. (Talk recorded in June 2009)

Nico Stuurman
Duration: 39:58

Christian Tischer

Christian Tischer studied physics in Heidelberg, followed by Ph.D. at the European Molecular Biology Laboratory (EMBL) with Dr. Philippe Bastiaens working on microscope development and signalling in mammalian cells. Subsequently, he did a postdoc with Dr. Marileen Dogertom at AMOLF in the Netherlands, where he worked on microtubule dynamics. From 2009 until 2018, he worked…

Endoplasmic Reticulum Membrane Contact Sites

The endoplasmic reticulum (ER) is a dynamic network of tubules that reaches throughout a cell. It interacts with other organelles at membrane contact sites. As Dr. Gia Voeltz explains, these sites are critical for Ca2+ regulation, lipid transport and defining sites of division for endosomes and other organelles. (Talk recorded in January 2019)

Ron Vale (President/Chairman of the Board)

Ron founded iBiology in 2006 and continues to oversee the project as President  and Chairman of the Board. Ron is a Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco and an investigator of the Howard Hughes Medical Institute. His lab studies spatial organization, movement, and signaling within cells. Ron, a…

Discovery Talk Questions and Answers: Unfolding the UPR

Peter Walter Assessments created by Dr. Yi Liu Questions In his talk, Dr.Walter briefly introduced endoplasmic reticulum (ER). Which of the following statement(s) is true (select all that apply)? Proteins enter the ER in an unfolded state as they come out of the ribosome. Proteins fold in the ER Proteins assemble into multi-subunit complexes in…

Discovery Talk Questions and Answers: The Dynamic Mitotic Spindle

Shinya Inoue  Assessments created by Dr. Delquin Gong Questions In his talk and in the paper, Dr. Inoue introduces the concept of birefringence. In simple terms, what is birefringence and why did Dr. Inoue need to use it for his cell division experiments? Dr. Inoue and his colleague used several methods to perturb the dividing…

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Learn the skills every scientist needs to succeed — for free. 🎧 On the go? Listen to the companion podcast! You’ll learn realistic strategies to navigate your own sticky research advisor situations. Testimonials for Our Courses “I wish I had this course as a beginning graduate student. I will definitely use all concepts in training my…

Kurt Thorn

Kurt Thorn is an Assistant Professor of Biochemistry and Biophysics at UCSF and Director of the Nikon Imaging Center – a facility that provides cutting edge light microscopy equipment to UCSF researchers. Kurt can be followed on his blog at http://nic.ucsf.edu/blog/.

Shinya Inoue

Dr. Inoue is a Distinguished Scientist at the Marine Biological Laboratory in Woods Hole, MA. He has made numerous contributions to microscopy and cell biology, including developing polarized light microscopy and video microscopy. Inoue was awarded the Order of the Sacred Treasure by the Government of Japan and is a member of the National Academy…

Imaging Synaptic Vesicle Transmission

Two pioneering electron microscopists, John Heuser and Tom Reese, reminisce about their early attempts to image synaptic vesicle transmission. (Talk recorded in July 2015)

How Muscle Contracts

Hugh Huxley describes the first definitive images showing that muscle was comprised of myosin and actin filament arrays that slide relative to each other when muscles contract. (Talk recorded in November 2011)

Hugh Huxley (Brandeis): How Muscle Contracts
Audience:
  • General Public
  • Student
  • Researcher
  • Educators of H. School / Intro Undergrad
  • Educators of Adv. Undergrad / Grad
Duration: 14:58

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Free Biology Lecture Videos Search our library of hundreds of in-depth biology lecture videos presented by the scientists behind the discoveries. Free Online Courses for Scientists We offer a bevy of free professional development and research skills courses for early career scientists and trainees. Free Educator Resources We provide free educator resources for our content,…

Philipp Keller

Dr. Philipp Keller earned his Master of Science in Physics at the University of Karlsruhe and at the University of Heidelberg in 2005. He continued his graduate studies at the European Molecular Biology Laboratory (EMBL). After a short postdoc at EMBL, he joined the faculty at HHMI’s Janelia Research Campus in 2010. His lab uses…

Techniques

A big part of advancing research is developing new techniques. These videos highlight how scientists have developed novel techniques to address important questions in biology. Techniques Microscopy Series Short Microscopy Series

Discovery Talk Questions and Answers: How Muscle Contracts

Hugh Huxley Assessments created by Dr. Rachna Sharma Questions What was the specific research problem pursued by Dr. Huxley? The energetics of muscle. The biochemistry of muscle. The mechanics of muscle. The submicroscopic structure of muscle. None of the above  What was Dr. Huxley able to show using X-Ray technology and a projection of the…

Protein Localization Inside Cells

How does the cell regulate protein localization to be sure that proteins end up where they should? Manu Hegde reviews experiments that answer this question. (Talk recorded in April 2017)

Ernst Stelzer

Dr. Stelzer trained as a physicist and has used his expertise to develop numerous optical techniques for studying problems in the life sciences. Currently his lab focuses on using light sheet-based fluorescence microscopy to study cells cultured in 3D. Stelzer is Vice-Director of the Buchmann Institute for Molecular Life Sciences and Professor in the Life…

Thomas Reese

Tom Reese is a Senior Investigator at the National Institute of Neurological Diseases and Stroke at the National Institutes of Health and a summer researcher at the Marine Biological Laboratory. He continues to study synaptic structure and function using advanced light and electron microscopy techniques. Reese was elected to the National Academy of Sciences in…

Erik Jorgensen

Erik Jorgensen is a Distinguished Professor of Biology and a member of the Program in Neuroscience at the University of Utah, and an Investigator of the Howard Hughes Medical Institute.  His lab studies the molecular mechanisms of synaptic transmission with a focus on synaptic vesicle fusion and recycling.  Jorgensen’s lab uses genetics, biochemistry, light and…

Developing Single Molecule Technologies to Study Nanomachines

Taekjip Ha explains the basis of FRET and how scientists have used single molecule technologies, in combination with other tools, to study nanomachines. (Talk recorded in May 2016)