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Home » Speakers » Ari Helenius
Ari Helenius

Ari Helenius

ETH

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Ari Helenius is from Finland where he studied Biochemistry in the University of Helsinki. During his PhD thesis work, which focussed on the analysis of membrane proteins, he and his colleagues started to work on the biochemical properties of enveloped animal viruses.

The simplicity and elegance of Semliki Forest virus and its membrane proved to be of great advantage in the analysis of basic membrane phenomena. Later while working as a staff scientist in the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, his work turned to the problem of virus cell interaction and virus entry. He and his colleagues demonstrated that many animal viruses enter cells by clathrin-mediated endocytosis, and that they possess spike glycoproteins with acid-activated membrane fusion activity.This allows their escape from endosomes.

Over the years as a Professor at Yale University Medical School and more recently in ETH Zurich, he and his group have continued to work on viruses and cells. In addition they have addressed basic cell biological questions such as protein folding in living cells, quality control, and secretion.

Talks with this Speaker

Viral Infection: Virus Entry and Subsequent Steps

Successful viral infection requires that a virus enters a cell and hijacks the host cell machinery to replicate its genome and make viral proteins. Ari Helenius tells us how this happens. (Talk recorded in February 2009)

  • Part 1: Virus Entry
    Part 1: Virus Entry
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 40:10
  • Part 2: Endocytosis and Penetration
    Part 2: Endocytosis and Penetration
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 30:18
  • Part 3: Open Sesame: Cell Entry and Vaccinia Virus
    Part 3: Open Sesame: Cell Entry and Vaccinia Virus
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 30:25

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. MCB-1052331. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speaker and do not necessarily represent the views of iBiology, the National Science Foundation, the National Institutes of Health, or other iBiology funders.

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