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Home » Speakers » Arthur Horwich
Arthur Horwich

Arthur Horwich

Yale University & Howard Hughes Medical Institute
Breakthrough Prize Canada Gairdner Award

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Arthur Horwich received his AB and MD from Brown University.  Following a pediatric residency at Yale, Horwich did two postdoctoral fellowships, first with Tony Hunter and Walter Eckhart at the Salk Institute and second with Leon Rosenberg at Yale, before joining the Yale faculty.

Currently, Horwich is Sterling Professor of Genetics and Pediatrics at Yale School of Medicine and an Investigator of the Howard Hughes Medical Institute.  He is interested in understanding how chaperonins promote the correct folding of proteins in the cell.  More recently, Horwich has focused his efforts on understanding the consequences of protein misfolding, particularly in ALS or Lou Gehrig’s disease.

Horwich is a member of the National Academy of Sciences and has received numerous awards for his work including the Gairdner International Award.  Together with his long time collaborator Franz-Ulrich Hartl, Horwich has been awarded the Wiley Prize, the Louisa Gross Horwitz Prize and the Albert Lasker Award for Basic Medical Research, among other prizes.

Talks with this Speaker

Chaperone-assisted protein folding I: Chaperonins

Arthur Horwich begins with a brief history of the discovery of the chaperonins and their importance in proper protein folding. (Talk recorded in July 2013)

  • Part 1: Chaperone-Assisted Protein Folding
    Part 1: Chaperone-Assisted Protein Folding
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 38:09
  • Part 2: Chaperone-Assisted Protein Folding
    Part 2: Chaperone-Assisted Protein Folding
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 20:26
  • Part 3: The Role of ATP Binding and Hydrolysis at GroEL
    Part 3: The Role of ATP Binding and Hydrolysis at GroEL
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 17:33
  • Part 4: Where are Proteins Folded by Chaperonins?
    Part 4: Where are Proteins Folded by Chaperonins?
    Audience:
    • Researcher
    • Educators of Adv. Undergrad / Grad
    Duration: 17:24

Discovery of Chaperonin-Assisted Protein Folding

Arthur Horwich talks about the story behind the discovery of the molecular chaperonin protein family and the role these chaperones play in protein folding. (Talk recorded in July 2012)

Arthur Horwich (Yale/HHMI): Discovery of chaperonin-assisted protein folding
Audience:
  • General Public
  • Student
  • Researcher
  • Educators of H. School / Intro Undergrad
  • Educators of Adv. Undergrad / Grad
Duration: 21:18

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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