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Home » Speakers » Shiv Pillai
Shiv Pillai

Shiv Pillai

Harvard Medical School

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Dr. Shiv Pillai is a professor of medicine and health sciences and technology at Harvard Medical School, and a Ragon Institute investigator. Pillai completed his medical studies at Christian Medical College Vellore, India (1976), and subsequently obtained his doctorate in biochemistry at Calcutta University, India. He continued his postdoctoral training at David Baltimore’s lab at MIT (1984-1988). It was at Baltimore’s lab where Pillai discovered the existence and importance of surrogate light chains for B cell development. The surrogate light chains bind the antibody heavy chain in pre-B cells (immature B cells), and form the pre-B cell receptor (pre-BCR). The signaling of pre-BCR is crucial for proper B-cell development. In 1988, he joined the faculty of Massachusetts General Hospital and Harvard Medical School. Today, his lab continues to study the basis of the immune system in order to provide further understanding to human disease.

Learn more about Pillai’s research at his lab website.

Talks with this Speaker

B Cell Development, Fundamental Questions in Immunology

Shiv Pillai provides a historical perspective on the steps that led to formulate today’s model on how the immune system works and outlines the underpinnings of B cell development. (Talk recorded in March 2018)

  • Part 1: Early B Cell Development: A Look at the Defining Questions in Immunology
    Part 1: Early B Cell Development: A Look at the Defining Questions in Immunology
    Audience:
    • Student
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 00:37:30
  • Part 2: Bruton Tyrosine Kinase Signaling: The pre-B Cell Receptor and B Cell Differentiation
    Part 2: Bruton Tyrosine Kinase Signaling: The pre-B Cell Receptor and B Cell Differentiation
    Audience:
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 00:23:27
  • Part 3:  IgG4-Related Disease: Collaboration Between B and T Cells
    Part 3: IgG4-Related Disease: Collaboration Between B and T Cells
    Audience:
    • Researcher
    • Educators of H. School / Intro Undergrad
    • Educators of Adv. Undergrad / Grad
    Duration: 00:26:54

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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