Description: Vale explains how doing science often follows a winding path with unexpected, sometimes wonderful surprises, and uses his own story to illustrate his point. When Vale was a graduate student, he initially hoped to show that myosin was involved in axonal transport, but ended up discovering a new molecule, which he called kinesin.
Length: 12:05 min Type: iBioEducation Topic: Cell biology
Description: Early microscopic images of cells and subcellular organelles were obtained using fixed cells. In this lecture, Dr. Inoue recalls how, in 1947, he built a polarizing light microscope that allowed him to visualize, for the first time, the dynamic mitotic spindle in live cells.
Length: 15:50 min Type: iBioEducation Topic: Cell biology
Description: Micrographs showing that the attachment of microtubules to chromosomes is required for movement to spindle poles during anaphase. Evidence that dynein might be responsible for this movement.
Length: 3:13 min Type: Short Clips Topic: Cell biology
Description: Discussion of the balance of forces in the mitotic spindle including the roles of kinesins 5 and 14 in the midzone and kinesin 13 at the poles. Microtubule dynamics are visualized by speckle microscopy.
Length: 4:10 min Type: Short Clips Topic: Cell biology