To better understand how an entire embryo develops from a single cell, Dr. Philipp Keller and colleagues developed a technique to image and quantitatively reconstruct mouse embryogenesis from gastrulation through early organogenesis at the single-cell level. Keller’s lab developed an adaptive light-sheet microscope to follow the mouse embryo for 48 hours while it’s developing its germ layers (mesoderm, endoderm, and ectoderm), early tissues, and organs. By combining long-term high-resolution imaging, computational, and statistical analyses, they generated a dynamic fate map of the embryo. These open-access resources aid in the understanding of the dynamic cell behaviors that allow for proper growth and development of the embryo.
Dr. Philipp Keller earned his Master of Science in Physics at the University of Karlsruhe and at the University of Heidelberg in 2005. He continued his graduate studies at the European Molecular Biology Laboratory (EMBL). After a short postdoc at EMBL, he joined the faculty at HHMI’s Janelia Research Campus in 2010. His lab uses… Continue Reading