Brangwynne tells us about recent work in which his lab has used light to control phase separation behavior in cells. By linking IDRs from proteins that are known to phase separate to protein domains that weakly oligomerize in response to light, his lab has generated tools that are allowing them to investigate the role of phase separation in different cell processes in many cell types.
View the full talk with additional resources on our website
Liquid Phase Separation in Living Cells
Liquid-liquid phase separation drives the formation of membrane-less organelles such as P granules and the nucleolus. Brangwynne explains how this process works and its important role in normal cell function and disease. (Talk recorded in July 2018)
- Part 1: Liquid Phase Separation in Living CellsAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 00:46:05 - Part 2: Multiphase Liquid Behavior of the NucleusAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:38:09 - Part 3: Using Light to Study and Control Intracellular Phase BehaviorAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 00:34:40