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Home » Playlists » Famous Discoveries

Famous Discoveries

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Join some of the world’s most well-known scientists as they explore the details of how their major discoveries happened. From DNA replication to fossil discoveries, learn about the experiences and struggles that led them to make these major discoveries.

  • Gregor Mendel's Famous Genetics Experiment
    Gregor Mendel's Famous Genetics Experiment
  • History of CRISPR: Rodolphe Barrangou
    Stories of CRISPR
  • Genome Engineering with CRISPR-Cas9
    Genome Engineering with CRISPR-Cas9
  • Meselson Stahl Experiment
    Meselson Stahl Experiment
  • Discovery of the Structure of the Nucleosome: Karolin Luger
    Discovery of the Structure of the Nucleosome
  • Cryo-cooling Protein Crystals: The First 52 Years: David J. Haas
    Macromolecular Cryocrystallography
  • Genetic origin of cancer: J Michael Bishop
    Evidence for a Genetic Origin of Cancer
  • Discovery of Lung Surfactant
  • Understanding the Cell Cycle Regulators: Lee Hartwell
    Discovering the Cell Cycle Regulators
  • David Baltimore
    Discovering Reverse Transcriptase
  • Ruslan Medzhitov
    The Role of Toll-Like Receptors in the Control of Adaptive Immunity
  • Ian Gibbons
    The Discovery of Dynein
  • Michael Hall
    The Story of TOR
  • Torsten Wiesel
    Exploring the Visual Brain
  • Evelyn Witkin: The SOS Response in Bacteria
    The SOS Response in Bacteria
  • John Heuser and Tom Reese
    Imaging Synaptic Vesicle Transmission
  • Ron Vale kinesin
    Discovering Kinesin
  • Colleen Cavanaugh
    Chemosynthetic Symbioses: Living Together Can Be Fun
  • Nobel Prize - Collaboration in Science
  • When Stockholm Called
    When Stockholm Called
  • Development of Optogenetics: Karl Deisseroth
    Development of Optogenetics
  • David Julius
    Sensory Receptors for Temperature and Pain
  • Niel Shubin
    Finding Tiktaalik, the Fossil Link Between Fish and Land Animals
  • Micheal Rosbash
    Understanding Circadian Rhythms
  • Wieschaus and NussleinVolhard
    Collaborating to Find Developmental Genes
  • Edmond Fischer
    Reversible Protein Phosphorylation
  • Jennifer Doudna
    Genome Engineering with CRISPR-Cas9
  • Developing One of the First Methods for Sequencing DNA
  • Phillip A. Sharp (MIT): RNA Splicing
    RNA Splicing: What is a Gene?
  • J. Woodland Hastings
    Autoinduction: The Discovery of Quorum Sensing in Bacteria
  • Alexander Rich
    The Discovery of Polynucleotide Hybridization
  • The Causes of Obesity and the Discovery of Leptin
  • Uncovering the Secretory Pathway
  • Familial Hypercholesterolemia
  • Gary Ruvkun
    The Small RNA Revolution: A Perfect Storm and Small Non-coding RNAs
  • Erling Norrby: DNA and the Nobel Prize
    DNA and the Nobel Prize: The History of the Discovery of DNA Structure
  • Joseph Gall: In Situ Hybridization
    In Situ Hybridization
  • Arthur Horwich (Yale/HHMI): Discovery of chaperonin-assisted protein folding
    Discovery of Chaperonin-Assisted Protein Folding
  • Elizabeth Blackburn
    Discovery of Telomeric DNA and Telomerase
  • Paul Berg
    Making the First Recombinant DNA Molecule
  • Eric Wieschaus
    Finding Genes that Control Development
  • Peter Walter (UCSF/HHMI): Unfolding the UPR
    Unfolding the UPR or the Unfolded Protein Response
  • Shinya Inoue: The Dynamic Mitotic Spindle
    The Dynamic Mitotic Spindle
  • Hugh Huxley (Brandeis): How Muscle Contracts
    How Muscle Contracts
  • Martin Chalfie (Columbia University): Developing GFP as a Biological Marker
    Developing GFP as a Biological Marker
  • Gary Borisy and Edwin Taylor
    The Discovery of Tubulin
  • Thomas Reese (NIH/MBL): Visualizing Synaptic Signaling
    Visualizing Synaptic Vesicles Signaling
  • Matthew Meselson Semi Conservative Replication
    The Semi-Conservative Replication of DNA
  • Mario Capecchi
    The Birth of Gene Targeting
  • Susan Desmond-Hellmann
    Drug Development – the Herceptin Story
  • H. Robert Horvitz (MIT/HHMI): Discovering Programmed Cell Death
    Discovering Programmed Cell Death
  • Eric Betzig and Harald Hess
    Developing PALM microscopy
  • Cynthia Kenyon (UCSF): A Genetic Control Circuit for Aging
    A Genetic Control Circuit for Aging
  • Tom Cech: Discovering Ribozymes
    Discovering Ribozymes
  • SNURPs and Serendipity: Joan Steitz
    SNURPs and Serendipity

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This material is based upon work supported by the National Science Foundation and the National Institute of General Medical Sciences under Grant No. 2122350 and 1 R25 GM139147. Any opinion, finding, conclusion, or recommendation expressed in these videos are solely those of the speakers and do not necessarily represent the views of the Science Communication Lab/iBiology, the National Science Foundation, the National Institutes of Health, or other Science Communication Lab funders.

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