Proteins that are secreted from the cell or inserted into the plasma membrane transit through the endoplasmic reticulum, where they are properly folded and assembled and may undergo post-translational modification. Walter tells the story of the exciting discovery made in his lab of the “unfolded protein response”, a feedback pathway that ensures that the cell makes enough ER to properly modify all the secreted proteins in the cell.
As well as being a skilled artisan, Peter Walter is Professor of Biochemistry and Biophysics at the University of California, San Francisco and a Howard Hughes Medical Institute Investigator. His lab studies how cells regulate the quantity of their organelles and how proteins localize to the right place within a cell. Walter is also a… Continue Reading