The nucleosome is the central organizing structure of the eukaryotic genome. It consists of DNA wrapped around histone proteins. Dr. Karolin Luger shares her discovery of the three-dimensional structure of the nucleosome using X-ray crystallography, which provided a deeper understanding of chromatin organization.
Karolin Luger earned her bachelor’s degree in microbiology and her master’s degree in biochemistry from the University of Innsbruck. She completed her PhD in biochemistry and biophysics at the University of Basel. In 1997, she published the first high-resolution 3D structure of the nucleosome, determined using X-ray crystallography. The Luger Lab uses structural biology to… Continue Reading