Drubin explains how he and his lab transferred their knowledge of endocytosis in yeast to determine how actin dynamics are harnessed to drive endocytic traffic in mammalian cells. In mammalian cells, his team observed the importance of actin-dynamin interactions in clathrin-dependent endocytosis. Interestingly, they found variability in endocytic site morphology and dynamics. Studies using stem cells suggested that this diversity in actin-mediated endocytosis is important for determining cell identity and development.
View the full talk with additional resources on our website
Actin Dynamics and Endocytosis in Yeast and Mammalian Cells
In this series of videos, Dr. David Drubin describes the critical link between actin dynamics and endocytosis in both budding yeast and mammalian cells. (Talk recorded in October 2017)
- Part 1: Introduction: Actin, Endocytosis and the Early Days of Yeast Cell BiologyAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 25:09 - Part 2: Actin Dynamics and Endocytosis in YeastAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 30:25 - Part 3: Actin Dynamics and Endocytosis in Mammalian CellsAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 35:12 - Part 4: Actin Assembly in Budding YeastAudience:
- Researcher
- Educators
- Educators of Adv. Undergrad / Grad
Duration: 28:37