Harland introduces the signaling molecules responsible for specifying distinct tissues in the embryo. He explains how signaling effectors, such as beta-catenin and Nodal/PSmad2, become localized in the blastula by determinants set up in the egg, and how these signals induce the formation of the mesoderm layer. He also describes classic experiments from the 1990s showing that the organizer is necessary to pattern the mesoderm into tissues such as muscle and neural plate. Harland then focuses on experiments from his lab that identified the molecules expressed in the organizer that specify dorsal cell fate.
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Early Frog Development: How to Make a Tadpole
Xenopus laevis, is an excellent model to study vertebrate development. Richard Harland outlines frog development including the cell movements and molecular signals of gastrulation. (Talk recorded in October 2017)
- Part 1: Early Frog Development: How to Make a TadpoleAudience:
- Student
- Researcher
- Educators of H. School / Intro Undergrad
- Educators of Adv. Undergrad / Grad
Duration: 24:58 - Part 2: The Cellular Basis of GastrulationAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 17:35 - Part 3: Early Frog Development: How to Make a Tadpole or a TwinAudience:
- Researcher
- Educators of Adv. Undergrad / Grad
Duration: 35:03