How do neurons develop to confer humans their unique brain functions? Dr. Arnold Kriegstein compares and contrasts the development of neurons from radial glial cells (RGCs) in mice and humans. In mice, RGCs give rise to most of the central nervous system’s neurons and glia and provide scaffolding for neurons to migrate. In contrast, human RGCs give rise to a unique set of cells, the outer subventricular zone radial glia (oRG) cells, which divide via mitotic somal translocation (MST). The oRG cells predominantly produce and guide the migration of the upper layer cortical neurons. Although rodents have oRG-like cells, these cells are more abundant in humans, and contribute to the large size of the human brain and possibly its unique function.
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Brain Development: Discovery and Characterization of Outer Subventricular Zone Radial Glia Cells
Dr. Arnold Kriegstein characterizes the development of neurons from radial glial cells and provides an overview of the use of cerebral organoids to study brain development and disease. (Talk recorded in October 2019)
- Part 1: The Importance of Outer Subventricular Zone Radial Glia Cells: New Concepts of Human Brain DevelopmentAudience:
- Researcher
- Educators
- Educators of Adv. Undergrad / Grad
Duration: 00:31:05 - Part 2: Cerebral Organoids: Models of Human Brain Disease and EvolutionAudience:
- Researcher
- Educators
- Educators of Adv. Undergrad / Grad
Duration: 00:32:58